Validations RequestAdvantaFlex LogoAdvantaFlex®: Biopharmaceutical Grade TPE Tubing

Sterile Weldable, Heat Sealable Bioprocess Tubing

high pressure burst testhigh pressure burst testAdvantaFlex addresses the need for a flexible, translucent, sterilizable, moldable, heat sealable, and weldable biopharmaceutical tubing for fluid processing. AdvantaFlex TPE tubing maintains its physical properties following sterilization processes, resists kinking, remains translucent for visible product flow, and does not become gummy. Full BPOG standardized extractables test protocol has been performed by a fully-accredited, third-party test lab.

KEY FEATURES

    • Animal Derived Ingredient Free
    • Sterile weldable and heat sealable
    • Available as leak-proof molded connections and tubing
    • Made from FDA-approved ingredients
    • Certified free of silicone oils and animal-derived ingredients
    • Sterilizable by autoclave or gamma radiation
    • Available with validated sterility assurance of 10-6 via gamma irradiation per ISO 11137 method VDmax 25
    • Meets various ISO and USP standards, including Class VI
    • Meets European Pharmacopoeia 3.2.2.1 standards
    • REACH, RoHS and California Proposition 65 compliant
    • Excellent low absorption and adsorption characteristics as compared to silicone
    • Low permeability as compared to silicone
    • Smooth interior for excellent flow and performance
    • Translucent for fluid flow visibility
    • Excellent tubing component for Single-Use systems
    • Sizes from 1/8″ (.125) through 1″ (1.000) I.D.
    • Custom lengths, sizes, and packaging available
    • Supplied double bagged; sealed in polybags at manufacture for cleanliness
    • Documented lot traceable with identification on packaging
    • Documented quality control per ISO 9001:2015
    • Single resin validation — no need to graft to other tubing materials like silicone for media filling and sampling applications that involve peristaltic pumps; helps eliminate operator errors
    • “Extractables” test portfolio available upon request
    • Included in our Rx-360 Joint Audit Program for Single-Use Systems
    • Complete validation package available upon request
    • Also available as sealed tubing ends
    • Single-Use AdvantaFlex tubing is available with molded mini Tri-Clamp® ends
    • Single-use Systems can be custom made using AdvantaSil® platinum-cured, Class VI silicone tubing and hose or AdvantaFlex® Class VI biopharmaceutical grade tubing.
    • Full BPOG standardized extractables test results available on request

There is a Better Alternative
Discover how much better the right tubing — AdvantaFlex — will work in your pharmaceutical, biotech, medical, or other critical processing application.

AdvantaFlex Weld Strength

WELD TEST VIDEO


APPLICATIONS

  • AdvantaFlex with bagsSterile filling
  • Vaccine production
  • Pharmaceutical sampling and delivery systems
  • Single-use systems
  • Bioreactor processes
  • Cell media, harvesting, and fermentation
  • Pharmaceutical production and processing
  • High purity water transfer
  • Filtration

Because of its ability to be sealed and welded, AdvantaFlex is ideal for filling and sampling applications.


SPECIFICATIONS

AdvantaFlex Biopharmaceutical TPE tubing

ADVANTAFLEX® – BIOPHARMACEUTICAL GRADE TPE

Part Number I.D. Wall (reference) O.D. Working Pressure at 70°F (21.1°C) Standard Lengths Coiled Standard Lengths on Spools
(in.) (mm.) (in.) (mm.) (in.) (mm.) PSI Bar (ft.) (ft.)
APAF-BP-0125-0250 .125 3.18 .062 1.57 .250 6.35 30 2.1 50, 100 500
APAF-BP-0188-0313 .188 4.76 .062 1.57 .313 7.94 23 1.6 50, 100
APAF-BP-0188-0375 .188 4.76 .094 2.38 .375 9.52 32 2.2 50, 100
APAF-BP-0250-0375 .250 6.35 .063 1.59 .375 9.52 20 1.4 50, 100
APAF-BP-0250-0438 .250 6.35 .094 2.38 .438 11.11 23 1.6 50, 100 300
APAF-BP-0250-0500 .250 6.35 .125 3.18 .500 12.70 30 2.1 50
APAF-BP-0313-0438 .313 7.94 .062 1.57 .438 11.11 21 1.4 50, 100 300
APAF-BP-0313-0500 .313 7.94 .094 2.38 .500 12.70 24 1.6 50
APAF-BP-0375-0500 .375 9.52 .062 1.57 .500 12.70 18 1.3 100
APAF-BP-0375-0563 .375 9.52 .094 2.39 .563 14.30 23 1.6 50
APAF-BP-0375-0625 .375 9.52 .125 3.18 .625 15.88 24 1.6 50, 100 150
APAF-BP-0500-0750 .500 12.70 .125 3.18 .750 19.09 22 1.5 50, 100 100
APAF-BP-0625-0875 .625 15.88 .125 3.18 .875 22.23 18 1.3 50
APAF-BP-0750-1000 .750 19.05 .125 3.18 1.000 25.40 17 1.2 50, 100 75
APAF-BP-0750-1125 .750 19.05 .188 4.76 1.125 28.58 18 1.3 100
APAF-BP-1000-1375 1.000 25.40 .188 4.76 1.375 34.93 18 1.3 25

Sold by standard lengths only. Add length suffix code to product number when ordering—see the Coil Length Legend at right for length suffix codes. Example: a 50 foot coil of .125 inch I.D. x .250 inch O.D. tubing is product number APAF-BP-0125-0250L. Add length and “S” to denote “spool” for products with lengths available on spools. Example: a 500 foot spool of .125 inch I.D. x .250 inch O.D. tubing is product number APAF-BP-0125-0250-500S. Working pressures are calculated from burst testing using a 3:1 safety factor. Coils and spools are supplied double bagged in heat-sealed polybags and bulk packed. Contact your AdvantaPure Sales Representative for other packaging options.

The data listed throughout this web site is meant only as a guide to aid in design, and is believed to be reliable; however, nothing stated shall constitute a guarantee or warranty for any application. Product field-testing should be performed to find the actual values for a specific application.

Coil Length Legend

P = 25 feet
L = 50 feet
K = 100 feet

PHYSICAL PROPERTIES

Specific Gravity .89
Durometer, Shore A±5 65
Ultimate Tensile Strength, PSI 1000
Ultimate Enlongation % 550
Tensile Modulus @100%, PSI 410
Tear Strength, Die B, PPI 240
Compression Set, % per ASTM D-395B 25
Max. Operating Temperature, °F 275
Brittle Temperature, °F -88

MOLDED ASSEMBLIES AND CONNECTIONS

  • AdvantaFlex molded connectionsAdvantaFlex MoldedBuild a complete single-use system from AdvantaFlex
  • Eliminates the need to splice silicone tubing sections into a process line
  • Reduce the number of barbed fittings and cable ties needed and their potential for contamination, leaks, and a wasted batch of product
  • AdvantaFlex molded connections provide a smooth inner surface for even, unrestricted flow
  • Choose from T’s, Y’s, reducers, couplers, crosses, mini and standard Tri-Clamps®, BioClosure® container closures and inserts such as GL45’s
  • Available with validated sterility assurance of 10-6 via gamma irradiation per ISO 11137 method VDmax 25
 

filling assembliesFILLING ASSEMBLIES

Sterile molded filling assemblies from AdvantaPure continue the shift to Single-Use processes that save time and reduce the risk of cross contamination while increasing productivity between batches. Manufactured with a focus on quality, the assemblies can be quickly installed and operational in a fraction of time as compared to traditional systems used in pharmaceutical and biotech filling.

MORE ABOUT MOLDED FILLING ASSEMBLIES


BIOCLOSURE SYSTEM ASSEMBLIESBIOCLOSURE SYSTEM ASSEMBLIES

animal derived indgediantsStandardized configurations for media bottles, flasks and carboys using AdvantaFlex Biopharmaceutical Grade TPE tubing and molded components are available.

MORE ABOUT BIOCLOSURE SYSTEM ASSEMBLIES


bioreactor tubingBIOREACTOR TUBING KITS

The Single-Use kits are custom manufactured and assembled from a variety of components — tubing, filters, connectors — to meet your needs. Made from platinum-cured silicone or AdvantaFlex® biopharmaceutical grade TPE tubing, AdvantaPure’s Bioreactor Tubing Kits provide convenience and greater efficiency.

MORE ABOUT BIOREACTOR TUBING KITS

 
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