BioClosure System Assemblies, made from AdvantaFlex® biopharmaceutical grade TPE, provide a ready to use, cost effective solution to reduce assembly time and eliminate cleaning validations. The Single-Use, closed cap system features a robust design to protect product integrity and decrease the risk of contamination. BioClosure System Assemblies are an ideal choice for bioprocessing applications such as aseptic sampling, cell growth and filling.

Full BPOG standardized extractables test protocol has been performed by a fully-accredited, third-party test lab; applies to AdvantaFlex closures and tubing only.

KEY FEATURES

• • • • 
    • All systems come preassembled with fluid transfer tubing for easy use
    • Meets various ISO and USP standards, including Class VI
    • Assembled and packaged in Class 7 (Class 10,000) ISO-certified clean rooms
    • Easy connections – AdvantaFlex tubing is sterile weldable and heat sealable
    • AdvantaFlex tubing is certified free of animal-derived ingredients
    • Documented lot traceable with identification on packaging
    • Documented quality control per ISO 9001:2015
    • AdvantaFlex validation and extractables test portfolios available upon request

  Full BPOG standardized extractables test results for AdvantaFlex closures and tubing are available on request

BioClosure Sterile Media Bottle Assemblies

• Available in five bottle capacities from 125 mL to 2 liter; square PETG bottles
• Validated sterility assurance of 10^-6 via gamma irradiation per ISO 11137 method VDmax 25
• AdvantaFlex® tubing supplied with plugged end and dip tube to bottom of bottle with angled cut for easy transfer
• 0.2 um filter for sterile gas venting
• Custom lengths and configurations available upon request
• Also available in platinum cured silicone

MORE INFO ON STERILE MEDIA BOTTLE ASSEMBLIES

BioClosure Sterile Erlenmeyer Flask Assemblies

• Available in two capacities: 1 and 2 liter; polycarbonate flasks
• Flasks fit standard shaking incubator systems and can be placed on any platform
• Validated sterility assurance of 10^-6 via gamma irradiation per ISO 11137 method VDmax 25
• AdvantaFlex® tubing with MPC/sealing cap and dip tube to bottom of flask with angled cut for easy transfer
• 0.2 um filter for sterile gas venting
• Custom lengths and configurations available upon request
• Also available in platinum cured silicone

MORE INFO ON STERILE ERLENMEYER FLASK ASSEMBLIES

BioClosure Cap Assemblies for AdvantaPure Carboys

• Available in five carboy cap capacities from 2.5 to 40 liter
• 2-port and 3-port closure configurations
• Fit carboys with 80mm and 120mm neck size
• Can be sterilized via gamma irradiation or autoclave
• AdvantaFlex® tubing with plugged end and dip tube to bottom of carboy for easy transfer
• 0.2 um filter for sterile gas venting
• BioClosure assemblies for 20 liter and 40 liter carboys include an adapter cone
• Custom lengths and configurations available upon request
• Also available in platinum cured silicone

MORE INFO ON CAP ASSEMBLIES AND CARBOYS

BioClosure Container Closure Systems

High Purity Container Closures

• Stoppers, caps, inserts for True Unions, GL45’s and other styles, with or without tubing, are available.

MORE INFO ON BIOCLOSURE SYSTEMS

Download a printable version of our BioClosure System Assemblies brochure. BioClosure_System_Assemblies.pdf (685kb)

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